Extracellular Matrix Presentation Modulates Vascular Smooth Muscle Cell Mechanotransduction
نویسندگان
چکیده
منابع مشابه
SM22 Modulates Vascular Smooth Muscle Cell Phenotype During Atherogenesis
The function of cytoskeletal proteins in the modulation of vascular smooth muscle cell (SMC) phenotype during vascular disease is poorly understood. In this report, we used a combination of gene targeting and Cre/loxmediated cell fate mapping in mice to investigate the role of SM22 , an SMC-specific cytoskeletal protein of unknown function, in the development of atherosclerosis. In hypercholest...
متن کاملExtracellular matrix and pulmonary hypertension: control of vascular smooth muscle cell contractility.
Pulmonary hypertension is characterized by increased vascular resistance due to smooth muscle cell hyperactivity and excess deposition of extracellular matrix (ECM) in the vessel wall. We investigated the possibility that changes in cell-ECM interactions may play an active role in this process by modifying the contractile response of pulmonary vascular smooth muscle (PVSM) cells. Contractility ...
متن کاملMechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype.
The vascular smooth muscle cell (VSMC) is surrounded by a complex extracellular matrix that provides and modulates a variety of biochemical and mechanical cues that guide cell function. Conventional two-dimensional monolayer culture systems recreate only a portion of the cellular environment, and therefore there is increasing interest in developing more physiologically relevant three-dimensiona...
متن کاملExtracellular matrix glycoprotein biglycan enhances vascular smooth muscle cell proliferation and migration.
Proteoglycans are produced and secreted by vascular smooth muscle cells, but the pathophysiological role of these glycoproteins in the vasculature is an enigma. Because the small leucine-rich proteoglycan (SLRP) biglycan is overexpressed in arteriosclerotic lesions, we produced mice constitutively overexpressing biglycan in the vascular smooth muscle, in order to examine the effects on vascular...
متن کاملGlucocorticoid inhibition of vascular smooth muscle cell proliferation: influence of homologous extracellular matrix and serum mitogens
We examined the influence of glucocorticoid hormones on the proliferation of cultured adult bovine aortic smooth muscle cells (BASM) using both primary mass cultures and a cloned strain. Cloned BASM cells maintained on plastic culture dishes were inhibited by approximately 40% by dexamethasone treatment but showed no inhibition when grown of homologous extracellular matrix (ECM) coated dishes. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.3073